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audio is usually 44.1kHz or 48kHz
16kHz means someone messed up.
and this is probably a h264 file.
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but also with audio you need to be super conservative on system spec- as the frame rates of movie dont exactly match the video frame rates.
i have a show at ENO this week - very high profile video/audio - mike figgis - and we run 1 layer of video with audio with 60Hz output -
so we use catalyst playback set to 60fps - not 25 or 30fps-
because this produces the lowest possible frame misses when playing audio - its also prores HQ 1080.