Im having the same issue -
Can you try something:

Create a blank show in a few folder with n561
setup content layers etc
save a preset
then go edit it
Does it work?
(mine did)

THEN - quit catalyst
then re-open the same show
try and edit the preset?
does it work?
(mine didnt)

Then just open and close M466B
and go back and open n561 show
does it work
(mine did!!)
confused? - me too….

S