Both should work - its just a mix.

However - pixelmad will only work in a mix which appears on OUTPUT 1...
So if you need to do a full screen output - then use OUTPUT 2 (ie your layers 1-10)
and move the PixelMad mix (your mix 1) to OUTPUT 1 (same output as the main primary mac desktop)

Assuming you have done everything else correctly - check this first, else do get back to me and post your showfile and I'll take a quick look.

Simon