I just seemed to be getting some very strange behaviour on screen 2, could have just been some conveniently positioned windows on screen 1. Will definitely post some screen grabs if i can replicate something that I see as an issue.

The issue I am still definitely having is that the mix 2 output doesn't appear in the pixelmad window and neither does the green resize box if the mix is unlocked in pixelmad, but i do get output and it changes location depending on where the green box is in the catalyst window if adjusting it's position using the "mix options" dialog.

Thanks again.